Nasopharyngeal carcinoma in Uganda

Nasopharyngeal carcinoma in situ in nasopharyngeal carcinoma.

AIMS To assess the presence of carcinoma in situ (CIS) in patients with nasopharyngeal carcinoma (NPC) and to see if the number of biopsy sites facilitates detection of CIS. METHODS Formalin fixed, paraffin wax embedded biopsy specimens (n = 285) from 187 patients with NPC in 1987 were studied for the presence of CIS as well as for the histological assessment of the subtype of CIS. RESULTS ...

MicroRNAs in nasopharyngeal carcinoma

It is becoming increasingly evident that aberrantly expressed microRNAs (miRNAs) are responsible for a number of disease processes, including cancer initiation and progression. miRNAs have been implicated as key players in numerous neoplasms, including nasopharyngeal carcinoma (NPC). Functionally, deregulation of miRNAs that act either as tumour suppressors or oncogenes results in numerous canc...

Exosomes in Nasopharyngeal Carcinoma

Exosomes are nanosized (30-100nm) membrane microvesicles secreted through a complex cellular process. Exosomes contain a variety of bioactive molecules, such as proteins, microRNAs(miRNAs or miRs) and long non-coding RNAs (lncRNAs), playing an important role in the cell-to-cell substance transportation and signal transduction. Nasopharyngeal carcinoma-related exosomes (NPC-Exo) have been identi...

Epigenetics in Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma in children.

asopharyngeal carcinoma is rare in children and adolescents. Nevertheless, it is considered to be Ihe only tumour of surface epithelium afflicting children and young adults. Three such cases seen om a period of eight years (1990-1997) are reported with a review of relevant literature. sopharyngeal carcinoma IS not an uncommon of head and neck region in adults, more so in the risl areas of South...